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M9460566.TXT
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1994-06-25
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Document 0566
DOCN M9460566
TI Absence of HTLV-1 related sequences in MS from high prevalence areas in
western Norway.
DT 9408
AU Myhr KM; Frost P; Gronning M; Midgard R; Kalland KH; Helland DE; Nyland
HI; Department of Neurology, University of Bergen, Norway.
SO Acta Neurol Scand. 1994 Jan;89(1):65-8. Unique Identifier : AIDSLINE
MED/94233931
AB In Western Norway, long-term follow up epidemiological studies have
revealed significant increases in the incidence and prevalence rates of
multiple sclerosis (MS) in stable populations, indicating the impact of
exogenous factors. In this study 183 MS patients and 102 controls from
high prevalence areas in Western Norway were investigated for human
T-lymphotropic virus type I (HTLV-1) related sequences by polymerase
chain reaction. Using primers targeting the gag, pol and env genes in
the HTLV-1 provirus genome, no amplification products were detected in
the 183 MS patients or 102 controls. The results strongly suggest that
neither HTLV-1 nor a closely related retrovirus participate in the
aetiology of MS.
DE Adult Blotting, Southern Cross-Sectional Studies Female Human
HTLV-I Infections/*EPIDEMIOLOGY Incidence Male Middle Age Multiple
Sclerosis/*EPIDEMIOLOGY Norway/EPIDEMIOLOGY Polymerase Chain Reaction
Risk Factors Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).